if the puncture is too deep, an injection into the muscle occurs and the onset of action is too rapid; Danger of hypoglycaemia (rarely occurs with standard pen needles)
If the puncture is too shallow, an injection is made into the upper layers of the skin and the onset of action is greatly delayed
Faster onset of action with heat due to increased skin blood flow (sauna, hot bath, hot-water bottle)
Sport and movement bring faster and stronger insulin effect
“Splash pads” (lipohypertrophies) in the fatty tissue of the skin lead to a delayed, unpredictable effect of insulin. In the case of illness and fever, the insulin effect is weaker
human insulin sensitivity depends on the circadian rhythm
People over the age of 7 often have the highest insulin requirements in the morning, lower insulin requirements at noon and at night, and moderate insulin requirements in the evening hours
smaller amounts of insulin work faster and shorter, larger amounts slower and longer
for insulin doses over 30 IU, the insulin should be delivered in several small doses; e.g. B. Dose splitting at 31 IU to 15 IU and 16 IU to different sites
